Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells
Seagrave JC, Albrecht H, Park YS, et al.
Exp Lung Res. 2011;37(10):606-614.
Results from an in vitro study* suggest that guaifenesin could improve mucociliary clearance in humans by reducing the release and/or production of mucins, thereby altering mucus rheology.
*Using primary human airway epithelial cells differentiated by air-liquid interface culture. These cultures are a complex, organotypic human airway model, containing the major cell types: basal, ciliated, non-ciliated and goblet cells.
Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells
Seagrave J, Albrecht HH, Hill DB, Rogers DF, Solomon G.
Respir Res. 2012;13:98.
Results from another in vitro study using airway cells demonstrate that guaifenesin effectively reduces cellular content and secretion of MUC5AC, increases MTR, and alters mucus rheology, and may therefore be useful in treating airway mucus hypersecretion and mucostasis in airway diseases.